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Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function Inhibiting Aurora kinase A and JAK2 signal transduction pathways permits the differentiation of potent regulatory T cells while neutralizing alloreactive T cells and preventing graft-versus-host disease without impairing antitumor responses.

Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools A computational and experimental strategy assesses the immunogenicity risk of bioengineered therapeutic proteins. A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions PTK7 is a tumor-initiating cell antigen, which can be targeted with an antibody-drug conjugate to confer sustained tumor regressions. Pharmacological rescue of diabetic skeletal stem cell niches Local delivery of a missing growth factor to the skeletal stem cell niche restores bone healing in diabetic mice.

CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease CRISPR-mediated order tramadol australia repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease resulted in functional human leukocytes in mice after transplantation. Endomicroscope sheds light on cervical tissue A pilot study of a handheld fluorescence endomicroscope demonstrates both in vivo imaging and differentiation of normal from precancerous cervical tissue.

Tune into the rhythm of your bugs Diurnal changes in gut microbiota localization and function alter host physiology through circadian epigenetic and transcriptional changes. A weighty problem Altered dopamine signaling in obesity might decrease physical activity without contributing to weight gain. DAMPening the effects of trauma-induced inflammation Amine-containing polymers immobilized on mesh and placed at trauma sites scavenge biomolecules that initiate a damaging immune response.

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