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The available formulations of ATT are depicted in Tables I-IV. Many companies are manufacturing single drug formulations for children. Isoniazid, rifampicin and pyrazinamide are available in single formulations as liquid, tablets and capsules. Some of the tablets are dispersible in nature. Ethambutol is available only in tablet form Table Various combinations tramadol rx online rifampicin and isoniazid are available. Combinations of isoniazid, rifampicin and pyrazinamide are also manufactured by numerous companies.

None of the combinations are available as liquid preparation Table II. A few companies are also marketing combination of four drugs i. Table I - Single Drug FormulationsTable II - Rifampcin and Isoniazid Combinations. Product Tab R mg H mg Pharmaceutical Company 1. Macox plus kid 100 50 Macleod 3. Montonex kid 100 ordeg Plethico 4.

Optirifa plus 100 50 Troikaa 5. Rimactazid 100 50 Novartis 6. Ticinex kid 100 50 Themis 7. Rcinex 50 50 100 Lupin 8. Docina R kid B6 5mg 100 50 Ashok Pharma 9. Rimpinah DT 100 50 Lyka 10. Eufacin INH kid 100 100 Euphoric 11. Rcinex kid 100 100 Lupin 12. Rifa onljne 6 kid forte 200 150 Concept 13. Rifa i 6 kid 100 100 Concept 14. Binex kid 150 100 Biological E 15. Rifanex kid 100 100 Bestochem 16. Anticox II kid 150 100 Unichem 17. Ipcacin B6 6 - mg 100 100 Ipca 18.

It was found that there was a wide variation in the composition of single drug as well as combination preparations. Pyrazinamide is available in liquid as well as tablet form. Similarly, the quantity of each drug in two drug combinations is widely variable in different products. Rifarmpicin ordering tramadol from canada dispensed as 100 mg, 150 mg or 200 mg along with isoniazid as 50 mg, 100 mg and 150 mg per tablet. In three drug combinations the strength of rifampicin per tablet varies widely from 100 mg, order 180 tramadol cod mg, 150 mg to 225 mg.

Isoniazid is dispensed in onliine strength of 75 mg, 80 rtamadol, 100 mg and 150 mg per tablet and pyrazinamide is dispensed in the strength of 250 mg, 500 mg and 750 mg. Some of these formulations also contain vitamin B6. Same variation is prevalent in the four drug combination. According to rational drug therapy, combination of drugs eay be avoided. However as antitubercular treatment requires multidrug therapy for relatively longer duration with stringent compliance, use of drug combinations are justified.

The use of combination of drugs is advantageous only if the ratio of fixed doses corresponds to the needs of individual patients 8. To the best of our knowledge 26 companies are manufacturing antitubercular drugs in single or combination preparations for children in Indian market. The quantity of antitubercular drugs in these products is neither uniformly marketed nor the ratio of individual drugs is appropriate. This may create two practical problems. One, the pediatrician has to remember quantity of individual antitubercular drugs in different formulation and recall them at the time of prescribing them to the patient which may on occasions be difficult and confusing.

Second, as the ratio of drugs is not appropriate, dose of one of drugs in combination may either be given in higher doses or at suboptimal doses.